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Representative cases of two combined ligand-based (LB) and structure-based (SB) strategies leading to the discovery of potent inhibitors of (A) 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) and (B) histone deacetylase 8 (HDAC8) enzymes. LB and SB methods are highlighted in blue and green, respectively. VS: virtual screening.
