Table 2.
Etiologies of the documented infections by time period.
| Pre-engraftment (≤30days) | Intermediate and Late (>30days) | |||
|---|---|---|---|---|
| Only frequencies are shown in parenthesis | HaploSCT (n = 40) |
MRD/VUD/MMUD (n = 77) |
HaploSCT (n = 38) |
MRD/VUD/MMUD (n = 70) |
| Patients with ≥1 severe infection | 18 (45) | 31 (40) | 6 (16) | 22 (31) |
| Bacterial infections | 23 | 37 | 10 | 33 |
| Staphylococcus spp | 7 | 17 | 2 | 4 |
| Coagulase negative | 7 | 15 | 2 | 4 |
| Enterococcus spp | 3 | 3 | − | 4 |
| Streptococcus spp | 3 | 5 | 3 | 5 |
| S. pneumoniae | − | − | 2 | 4 |
| Gram-negative bacteria | 9 | 10 | 4 | 13 |
| C. difficile colitis | 1 | 1 | 1 | 5 |
| Other | − | 1 | − | 2 |
| IFI | 2 | 3 | 1 | 4 |
| IPA | 2 | 2 | 1 | 2 |
| Other | – | 1 | − | 2 |
| Viral infections | 14 | 6 | 49 | 73 |
| CMV | ||||
| Reactivation | 7 | 4 | 17 | 29 |
| Disease | − | − | 1 | − |
| EBV | − | − | 3 | − |
| Reactivation | − | − | 3 | − |
| PTLPD | − | − | − | − |
| HSV or VZV | − | – | 4 | 6 |
| HHV-6 encephalitis | 1 | − | − | 2 |
| Viral haemorrhagic cystitis | 4 | 1 | 8 | 5 |
| Community‐acquired respiratory virus | 2 | 1 | 14 | 27 |
| Others (highlight) | − | − | 2 | 4 |
MRD HLA-identical matched related donor, VUD HLA-matched volunteer unrelated donor, MMUR 1-allelel mismatched volunteer unrelated dono, CMV cytomegalovirus, EBV Epstein Barr virus, PTLPD post-transplant lymphoproliferative disorder, HVS Herpes simplex virus, VZV Varicella-zoster virus, HHV-6 Human herpesvirus 6, LRTI low respiratory tract infection.