Table 4.
Predicted activation state in the gut intestinal tract of day of hatch chicks. The table depicts top biological and disease functions with a predicted activation or inhibition relative to the saline (S) control group.
|
Categories |
Diseases or functions annotation |
P-value1 |
Z-score3 |
||||
|---|---|---|---|---|---|---|---|
| C | C2 | L | C | C2 | L | ||
| Carbohydrate metabolism | Synthesis of carbohydrate | -- | -- | <0.01 | -- | --2 | 1.91 |
| Cellular movement, Hematological system development and function, immune cell trafficking | Migration of cells | <0.01 | <0.01 | <0.01 | 2.10 | 2.24 | 1.57 |
| Cell movement of endothelial cells | <0.01 | -- | <0.01 | 2.00 | -- | -- | |
| Cell movement | <0.01 | <0.01 | -- | 2.24 | 2.31 | -- | |
| Invasion of cells | <0.01 | <0.01 | 2.30 | -- | -- | ||
| Protein synthesis | Metabolism of protein | <0.01 | -- | <0.01 | 1.71 | -- | -- |
| Synthesis of protein | <0.01 | -- | <0.01 | 1.45 | -- | -- | |
| Translation of protein | <0.01 | -- | <0.01 | 1.12 | -- | -- | |
| Free radical scavenging | Synthesis of reactive oxygen species | -- | -- | <0.01 | -- | -- | −1.88 |
| Production of reactive oxygen species | -- | -- | <0.01 | -- | -- | −1.46 | |
| Inflammatory response | Inflammation of organ | <0.01 | -- | -- | 2.21 | -- | -- |
| Cell-to-cell signaling | Aggregation of cells | <0.01 | -- | -- | 1.74 | -- | -- |
| Cell-cell contact | <0.01 | -- | -- | 2.59 | -- | -- | |
1
Significane generated in IPA was set at P ≤ 0.05 from Fisher's exact test.
2
-- = Z-score or P-value of overlap was not provided so no prediction could not be obtained.
3
All biological and disease functions that were predicted to be activated (Z-score ≥ 2.00) or inhibited (Z-score ≤ −2.00). Qualified predictions were categorized as high (Z-score ≥ |1.90| or more) medium (Z-score = |1.70 – 1.90|) or low (Z-score = |1.50 – 1.70|).