Table 1.
miRNAs have been reported to have regulatory roles during MDV infection in chickens.
| miRNA | Species | Source | Pattern | Targets | Cell function | Reference |
|---|---|---|---|---|---|---|
| let-7d | Chicken | Skin | Up | - | - | Heidari and Delekta, 2017 |
| miR-130a | Chicken | Spleens | Down | HOXA3, MDFIC | Inhibit MD lymphoma cell proliferation and migration | Han et al., 2016 |
| miR-140-3p | Chicken | Spleens | Down | - | Inhibit MDV-transformed lymphoid cells proliferation; MD lymphoma transformation | Lian et al., 2015 |
| miR-155 | Chicken | Cell lines, peripheral blood leukocytes | Up | GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1, C/EBP | - | Muylkens et al., 2010 |
| miR-155 | Chicken | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-15b | Chicken | Spleens | Down | ATF2 | - | Tian et al., 2012 |
| miR-199-3p | Chicken | Spleens | Down | - | Inhibit MDV-transformed lymphoid cells proliferation; MD lymphoma transformation | Lian et al., 2015 |
| miR-221 | Chicken | Cell lines | Up | p27(Kip1) | - | Lambeth et al., 2009 |
| miR-221-5p | Chicken | Spleens | Down | - | Inhibit MDV-transformed lymphoid cells proliferation; MD lymphoma transformation | Lian et al., 2015 |
| miR-222 | Chicken | Cell lines | Up | p27(Kip1) | - | Lambeth et al., 2009 |
| miR-26a | Chicken | Spleens | Down | NEK6 | Suppress MD lymphoma cell proliferation | Li, Lian, Zhang, Qu and Yang, 2014b |
| miR-29b | Chicken | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-762 | Chicken | Spleens | Down | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-12 | MDV | Cell lines, kidney or spleen tissues | Up | - | Potential biomarkers for MDV-transformed tumors and lymphoblastoid cell lines. | Xu et al., 2008 |
| miR-4 | MDV | Cell lines, kidney or spleen tissues | Up | - | Potential biomarkers for MDV-transformed tumors and lymphoblastoid cell lines. | Xu et al., 2008 |
| miR-8 | MDV | Cell lines, kidney or spleen tissues | Up | - | Potential biomarkers for MDV-transformed tumors and lymphoblastoid cell lines. | Xu et al., 2008 |
| miR-M1 | MDV | Cell lines, spleens | Up | - | Burnside et al., 2006 | |
| miR-M12-3p | MDV | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-M1-5p | MDV | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-M2 | MDV | Cell lines, spleens | Up | - | Burnside et al., 2006 | |
| miR-M2*/3p | MDV | Spleens | Up | - | - | Morgan et al., 2008 |
| miR-M2-5p | MDV | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-M3 | MDV | Cell lines, spleens | Up | - | Burnside et al., 2006 | |
| miR-M3-5p | MDV | Cell line | Up | - | - | Yao et al., 2008 |
| miR-M4 | MDV | Spleens | Up | - | - | Morgan et al., 2008 |
| miR-M4 | MDV | Embryo fibroblast cultures | Up | - | Variants within its seed region were sufficient to inhibit the induction of lymphomas. | Zhao et al., 2011 |
| miR-M4 | MDV | Cell lines, spleens | Up | - | Burnside et al., 2006 | |
| miR-M4 | MDV | Spleens | Up | - | - | Burnside and Morgan, 2011 |
| miR-M4-5p | MDV | Cell lines | Up | - | - | Yao et al., 2008 |
| miR-M4-5p | MDV | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
| miR-M4-5P | MDV | Cell lines, peripheral blood | Up | GPM6B, RREB1, c-Myb, MAP3K7IP, PU.1, C/EBP, UL28, UL32 | - | Muylkens et al., 2010 |
| miR-M5 | MDV | Cell lines, spleens | Up | - | - | Burnside et al., 2006 |
| miR-M5-3p | MDV | Cell lines | Up | - | - | Yao et al., 2008 |
| miR-M6-5p | MDV | Cell lines | Up | - | - | Yao et al., 2008 |
| miR-M7-5p | MDV | Cell lines | Up | - | - | Yao et al., 2008 |
| miR-M8-3p | MDV | Spleens | Up | - | - | Li, Zhang, Li, Zheng, Zheng and Liu, 2014c |
“-” Means no targets of the microRNA in the reference.
Abbreviations: MD, Marek's disease; MDV, Marek's disease virus; miRNA, microRNA.