Table 2.
miRNAs have been reported to play a regulatory role during ALV-J infection in chickens.
| miRNA | Source | Pattern | Targets | Cell function | Reference |
|---|---|---|---|---|---|
| let-7b | Liver | Down | - | - | Li et al., 2012 |
| let-7i | Liver | Down | - | - | Li et al., 2012 |
| miR-125b | Liver | Down | - | - | Li et al., 2012 |
| miR-125b | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-125b | Cell lines, liver | Down | - | - | Wang, Gao, Ji, Qi, Qin, Gao, Wang and Wang, 2013a |
| miR-130a | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-1456 | Liver | Up | - | - | Li et al., 2012 |
| miR-148a | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-1704 | Liver | Up | - | - | Li et al., 2012 |
| miR-1777 | Liver | Up | - | - | Li et al., 2012 |
| miR-1790 | Liver | Up | - | - | Li et al., 2012 |
| miR-193a | Cell lines, liver | Down | - | - | Wang, Gao, Ji, Qi, Qin, Gao, Wang and Wang, 2013a |
| miR-193b | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-193b | Cell lines, liver | Down | - | - | Wang, Gao, Ji, Qi, Qin, Gao, Wang and Wang, 2013a |
| miR-211 | Bone marrow dendritic cells | Down | - | - | Liu et al., 2016 |
| mir-2127 | Liver | Up | - | - | Li et al., 2012 |
| miR-222 | Liver | Up | - | - | Li et al., 2012 |
| miR-221 | Bone marrow dendritic cells | Down | - | - | Liu et al., 2016 |
| miR-221 | Cell line, liver tissue | Up | CDKN1B | Promote cell proliferation and cell cycle progression | Ren et al., 2018 |
| miR-221 | Liver | Up | - | - | Li et al., 2012 |
| miR-221 | Cell lines, liver | Up | BMF | Promote the proliferation, migration, and growth of cancer cells, and inhibit apoptosis | Dai et al., 2015 |
| miR-221 | Cell lines, liver | Up | - | - | Wang, Gao, Ji, Qi, Qin, Gao, Wang and Wang, 2013a |
| miR-222 | Liver, marrow | Up | BMF | Promote the proliferation, migration, and growth of cancer cells, and inhibit apoptosis | Dai et al., 2015 |
| miR-222a | Bone marrow dendritic cells | Down | - | - | Liu et al., 2016 |
| miR-23b | Spleens | Up | IRF1 | Promote ALV-J replication | Li et al., 2015a |
| miR-27b | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-34a | Bone marrow dendritic cells | Up | - | - | Liu et al., 2016 |
| miR-34b-5p | Spleens | Up | MDA5 | Promote ALV-J infected cells proliferation and ALV-J replication | Li et al., 2017 |
| mir-375 | Livers | Down | - | - | Li et al., 2012 |
| mir-458 | Livers | Down | - | - | Li et al., 2012 |
Abbreviations: ALV-J, avian leukosis virus subgroup J; BMF, BCL-2 modifying factor; miRNA, microRNA.