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. 2020 Oct 9;21(20):7432. doi: 10.3390/ijms21207432

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of hyperglycaemia on left ventricle (LV)-dysfunction. (A) Representative monodimensional echocardiographic imaging of normal pellet diet (NPD) and NPD + streptozotocin (STZ) groups at the end of the study. (B) Histograms show cardiac dimensions and functional parameters assessed at the end of the study. Hyperglycemia in NPD + STZ rats significantly increased LV end-systolic diameter (LVESd) and LV end-diastolic diameter (LVEDd), impairing fractional shortening (FS) and ejection fraction (EF) as compared with the NPD group. (C,D) In NPD + STZ animals, a significant thinning of interventricular septum in systole (IVSs) and in dyastole (IVSd) and (E,F) the reduction of left ventricular posterior wall in systole (LVPWs) and in diastole (LVPWd) were detected in comparison with the NPD group. (G,H) No differences in end diastolic left ventricular mass (EDLVM) and in end systolic left ventricular mass (ESLVM) were observed between the two groups. The data are presented as mean ± SEM. * p < 0.05 vs. NPD, Mann–Whitney test, n = 6/group.