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. 2020 Oct 9;21(20):7432. doi: 10.3390/ijms21207432

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of hyperglycaemia on MMP-2 activity and localization in myocardial tissue. (A) Zymogram showed a decreased activation of the extracellular MMP-2 (57 kDa) in NPD + STZ rats compared with the NPD group, whereas no difference of full-length FL-MMP-2 and N-terminal truncated isoform of MMP-2 (NT-MMP-2) activities was detected. (B) Representative images of immunofluorescence analysis. Orange staining is due to colocalization of mitochondria (MitoSOX™-induced coloration) with NT-MMP-2 (green). Blue/white staining is due to colocalization of endoplasmic reticulum (ER-Tracker™-induced blue) with NT-MMP-2 (green). * p < 0.05; vs. NPD. The data are presented as mean ± SEM, t-test n = 6/group.