Figure 6.

Photomicrographs representative of the spleen histology (5 µm) of groups of animals without and with S180 tumor, highlighting the limits of the white pulp (wp) and red pulp (rp). Control groups (A,B) are animals without and with tumor S180 treated with the vehicle (saline), respectively. Groups (C,D) are S180 tumor-bearing animals treated with PaLE 100 and 150 mg/kg/day, respectively. The positive control group (E) are S180 tumor-bearing animals treated with 5-fluorouracil 25 mg/kg/day. 100× magnification.