Table 5.
Effect of PaLE (i.p.) on hematological parameters of peripheral blood in mice with and without S180 tumor.
| Parameters | Healthy | Animal with Tumor | |||
|---|---|---|---|---|---|
| Saline | Saline |
PaLE 100 mg/kg/day |
PaLE 150 mg/kg/day |
5-FU 25 mg/kg/day |
|
| Total leukocytes (103 cels/µL) | 7.29 ± 0.76 * | 9.49 ± 0.37 # | 12.48 ± 0.55 * # | 13.84 ± 0.95 * # | 2.40 ± 0.37 * # |
| Lymphocytes % | 69.63 ± 1.19 * | 48.13 ± 2.36 # | 55.23 ± 4.76 * # | 54.40 ± 2.62 * # | 82.40 ± 1.29 * # |
| Monocytes % | 1.75 ± 0.53 | 1.63 ± 0.32 | 1.17 ± 0.31 | 1.60 ± 0.24 | 1.20 ± 0.20 |
| Neutrophils % | 28.62 ± 1.13 * | 50.25 ± 2.46 # | 43.60 ± 3.84 * # | 44.00 ± 1.70 * # | 16.40 ± 1.21 * # |
| Red cells (106/mL) | 7.83 ± 0.60 | 7.67 ± 0.61 | 8.00 ± 0.37 | 8.17 ± 0.79 | 7.50 ± 0.56 |
| Hemoglobin (g/dL) | 14.17 ± 0.54 | 13.17 ± 0.79 | 13.33 ± 0.92 | 13.50 ± 1.02 | 12.83 ± 1.14 |
| Hematocrit (%) | 43.17 ± 1.72 | 42.83 ± 1.70 | 43.67 ± 1.23 | 44.33 ± 2.17 | 42.67 ± 1.56 |
Data are presented as the mean ± the standard error of the mean of 6 animals. The results were evaluated by one-way ANOVA followed by Student Newman Keuls post-test. * p < 0.05 compared to the group of animals with tumor, treated with saline; # p < 0.05 compared to the group of animals without tumor, treated with saline. Saline was used as a negative control and 5-FU as a positive control.