Figure 1.

Schematic representation of the human CD38 gene. The red rectangles identify the single exons. The pink rectangle depicts the CpG island. The yellow circles indicate specific responsive elements in the regulatory region of the gene. The blue ellipses indicate regulatory interleukins for which no responsive element has been identified. The black diamond highlights the polymorphic site. ER, estrogen-responsive element; IRF, interferon-responsive element; RARE, retinoic acid-responsive element; E2, estrogen; SNP, single nucleotide polymorphism; RAR, retinoic acid receptor. Modified from [6].