Table 1.

Recoveries for the I₂-oxidation of the Acm₂-precursor peptide.

Organic Solvents	pH	Temperature	Recovery (%) a
50% AcOH	3	25	82
50% MeOH/0.1 M HCl	2	25	74
50% MeOH	7	25	30
50% MeOH/0.1 M NH3 aq	9	25	28
50% i-PrOH/0.1 M HCl	2	25	63
80% i-PrOH/0.1 M HCl	2	25	62
50% THF/0.05% TFA	2	25	71
50% THF/0.05% TFA	2	30	69
50% THF/0.05% TFA	2	40	64
50% THF/0.05% TFA	2	50	54
50% THF/0.05% TFA	2	60	36
50% THF/0.05% TFA	2	70	25
50% THF/0.05% TFA	2	80	19

^a The Acm₂-precursor peptide, [Cys(Acm)^7,15,2SS]-ST_h(6–18), was treated with iodine under various conditions. The recoveries of the topological isomer were determined by HPLC analysis.