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. 2020 Oct 14;16(10):e1008951. doi: 10.1371/journal.ppat.1008951

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© 2020 Kuo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — Groups of randomized, mixed sex three- to seven-week-old Ifnar1^-/- mice were subcutaneously inoculated with 10³ PFU of ZIKV-WTic and NS1 mutants (n = 8-11/strain). Mice were observed daily for 21 days and morbidity (A), mortality (B) and viremia (C) were measured. No significant differences in morbidity or mortality were identified. Strain had a significant impacted on viremia levels (Two-way ANOVA, p = 0.02). Viremia was significantly higher for ZIKV-V982A at 2 dpi compared to ZIKV-WTic, yet significantly lower for ZIKV-A894G at both 2 dpi and 4 dpi (*t-test, p<0.05). Viremia levels of ZIKV-NS1dm were equivalent to ZIKV-WTic at both 2 and 4 dpi (t-test, p>0.05).