Table 1. Biophysical Properties of FGF2 and Conjugates.
preparation | MW [kDa] | HMWa [kDa] | Tden [°C] |
---|---|---|---|
FGF2 | 17.2 | 17.4 | 54.5 |
FGF23xC-(vcMMAE)3 | 21.8 | 16.6 | |
FGF23xC-(tvAY)3 | 21.5 | 26.5 | 50.9 |
FGF23xC-(PEG4-tvAY)3 | 23.1 | 30.6 | 57.5 |
FGF23xC-(PEG27-tvAY)3 | 26.2 | 58.6 | 54.1 |
FGF21xC-PEG27-(tvAY)3 | 23.8 | 33.3 | 50.5 |
Equivalent protein molecular weights determined by SEC.