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. 2020 Jun 5;17(7):2734–2748. doi: 10.1021/acs.molpharmaceut.0c00419

Table 1. Biophysical Properties of FGF2 and Conjugates.

preparation MW [kDa] HMWa [kDa] Tden [°C]
FGF2 17.2 17.4 54.5
FGF23xC-(vcMMAE)3 21.8 16.6  
FGF23xC-(tvAY)3 21.5 26.5 50.9
FGF23xC-(PEG4-tvAY)3 23.1 30.6 57.5
FGF23xC-(PEG27-tvAY)3 26.2 58.6 54.1
FGF21xC-PEG27-(tvAY)3 23.8 33.3 50.5
a

Equivalent protein molecular weights determined by SEC.