Figure 3.

Interaction between aprepitant and itraconazole against different Candida species. (a) ƩFICI (fractional inhibitory concentration index) values were calculated from checkerboard assays. Cultures of C. albicans TWO7243, C. krusei ATCC 14243, C. tropicalis ATCC 1369, and C. parapsilosis ATCC 22019 were treated with APR (10 µg/ml) and ITC (0.25 × MIC), either alone or in combination. Treated cultures were incubated at 35°C for 24 h before being spotted onto YPD agar plates and reincubated for an additional 24 h. Plates were then scanned (b) and CFU count was performed (c)