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Effect of iron supplementation on the antifungal activity of aprepitant/itraconazole (APR/ITC). (a) Effect of iron supplement (FeSO4, at 50 µM) on the time-kill kinetics of aprepitant (10 µg/ml), itraconazole (1 µg/ml), or a combination of both drugs against C. auris AR0390. (b) Spot assays demonstrated the ability of iron supplementation to reverse the antifungal effect exerted by the aprepitant/itraconazole combination (10/1 µg/ml)
