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. 2020 Sep 24;9:e62514. doi: 10.7554/eLife.62514

Figure 7. Molecular and cellular mechanisms for force-activated binding by α-catenin.

Figure 7.

(A and B) Cartoons of two conceptual mechanistic models for force-activated actin binding by the α-catenin ABD. Orange box represents the force detector (residues 872–906) at the distal tip of the CTE. Blue gradient represents a force-induced conformational transition in the actin protomer. (C) Cartoon of proposed biological functions for force-activated actin binding by the two cellular populations of α-catenin. Membrane-associated cadherin-catenin complexes are illustrated in purple.