Table 1.
The effect of piperine on renal ischemia/reperfusion induced histopathologic damages.
| Histopathologic damages | Experimental groups |
|||
|---|---|---|---|---|
| Sham | IR | IR + P10 | IR + P20 | |
| Bowman's space enlargement | 0.1 | 5 | 3.4 | 1 |
| Tubular cell necrosis | 0 | 5 | 4.2 | 0.7 |
| Vascular congestion | 0.2 | 4.3 | 3.8 | 1.1 |
| Intra-tubular proteinaceous casts | 0 | 4.6 | 2.9 | 0.8 |
| Perivascular edema | 0 | 3.8 | 3.1 | 1.2 |
| Leukocyte infiltration | 0 | 5 | 3.3 | 0.6 |
| Total histopathologic score | 0.3 | 27.7 *** | 20.5 *** † | 5.4 * ††† |
Histopathological scores in rats underwent sham operation and received normal saline (Sham), ischemia/reperfusion and received normal saline (IR), or piperine at 10 or 20 mg/kg (IR + P10 and IR + P20).
*P < 0.05, ***P < 0.001, in comparison with control group.
†P < 0.05, †††P < 0.001, in comparison with IR group.