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. 2020 May 1;77(21):4289–4297. doi: 10.1007/s00018-020-03535-6

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© The Author(s) 2020

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Fig. 4 — Amino acid sensing by larval insulin producing cells. Two LAT-1 transporters (Minidiscs (Mnd) and Juvenile hormone Inducible-21 (JhI-21) are expressed in IPCs. Mnd is located on the endoplasmic reticulum; whereas JhI-21 is on the plasma membrane. They allow the transport of branched amino acids (Leucine and Isoleucine) that leads to the release of DILPs. DILPs are involved in metabolism regulation and in growth control. AA amino acids, ER endoplasmic reticulum, GDH glutamate dehydrogenase, LAT-1 large neutral amino acid transporter, Mnd Minidiscs