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. 2020 Sep 27;47(10):7783–7795. doi: 10.1007/s11033-020-05855-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Histopathology of glioblastoma-driven brain tumors. Hematoxylin and eosin staining of brain slice with colored boxes highlighting areas of particular interest for non-treated condition. a, b and c Non-treated condition, d and e Ator group, f and g MSCs group and h and i MSCs + Ator group. a Glomeruloid structure is a bizarre form of endothelial proliferation that comprise capillary tufts (black arrow) dispersed amidst a proliferation of endothelial cells and pericytes merged with necrosis, congestion and hemorrhage, b Pseudopalisading of neoplastic cells (black arrow) with severe necrosis (star) associated with microvascular proliferation (green arrow), c Pseudopalisading with moderate necrosis of neoplastic cells (black arrow) along with microvascular proliferation (green arrows), glomeruloid structures (arrows) dispersed amidst of endothelial cells and pericytes. d Pseudopalisading with moderate necrosis of neoplastic cells (black arrow), e small delicate vessels characterize the normal vasculature associated with dark neuron (green arrow), microglia cell (arrow head) and moderate cellularity of tumoral cells. f This glioblastoma has manifest cellularity, with noticeable hyperchromatism as well as pleomorphism. Note the prominent vascularity and the area of necrosis with neoplastic cells palisading around it, g marked cellularity, with marked hyperchromatism, pleomorphic neoplastic cells, multi-nucleoli and (arrow head), high mitotic index and calcification, Inset: four mitosis phases in control group, inset: high mitotic index associated with various mitotic figures including prophase (blue arrow head), metaphase (black arrow head) and anaphase (red arrow head. h Low hypercellularity (arrow head), low mitosis index and mild invasive tumor cells (arrow) show a predilection for perivascular cuffing without pseudopalisading necrosis, Inset: normal neuron and small delicate vessels; i Glomeruloid (black arrow) and mild or limited invasive tumoral cells associated with microvascular proliferation (green arrows) without pseudopalisading necrosis. (Color figure online)