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. 2020 Oct 26;10:18232. doi: 10.1038/s41598-020-75406-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results from a glycolytic stress test using CFS (n = 9) and healthy control (n = 10) skeletal muscle cells. Cells were untreated (white bars), treated with 1 µM compound 991 for 2 h (hatched bars), or treated with 2 mM metformin for 16 h (diagonal bars). For treated cells n = 7. (A) Glycolysis. (B) Glycolysis relative changes. (C) Glycolytic capacity. (D) Glycolytic capacity relative changes (E) Glycolytic reserve. (F) Glycolytic reserve relative changes. Groups were compared using two-way ANOVAs with post-hoc Bonferroni correction. HC healthy control; CFS CFS patient; ECAR extracellular acidification rate. a = differs significantly from untreated.