Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 26;10:18220. doi: 10.1038/s41598-020-75253-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

In vitro investigation of BBB opening via the integration of a semipermeable culture insert and FUS exposure setup. (a) A schematic diagram of the apparatus constructed for evaluating the FUS-induced enhancement of BBB permeability to nanoparticles. (b) Time change in TEER induced by FUS exposure in the presence of MBs. The effect of treatment with 10 μM regadenoson (Reg) was also evaluated for comparison. The arrow indicates the time when FUS exposure or Reg treatment was conducted (defined as 0 h). The control group was the BBB model that received no treatment. N = 4. (c) Immunohistochemical staining of the tight junction-associated protein ZO-1 (red) in bEnd.3 cells, with and without FUS exposure, observed using a confocal laser scanning microscope. Cell nuclei were also stained with DAPI (blue). The scale bar represents 10 μm.