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. 2020 Oct 26;10:18220. doi: 10.1038/s41598-020-75253-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of nanoparticle size on their permeability across the in vitro BBB model following its exposure to FUS. (a) TEM images of synthesized AuNPs with diameters of 3, 15, and 120 nm. Scale bar is 20 nm. (b) The amount of 3, 15, and 120 nm AuNPs that permeated across the in vitro BBB model following its exposure to FUS in the presence of MBs. The effect of treatment with 10 μM Reg was also evaluated for comparison. The control group was the BBB model without any treatment. **p < 0.01; *p < 0.05; N.S., not significant. N = 4.