Table 5.

Input feature overview.

Feature Group (no. features)	Features
Patient characteristics (4)	Age, sex, weight, height
Laboratory results (25)	Phosphate, total bilirubin, baseline creatinine, creatinine, baseline urea, urea, glomerular filtration rate, creatine kinase (CK), CK-MB, red blood count, white blood count, platelets, C-reactive protein, gamma-glutamyltransferase, glutamic oxaloacetic transaminase, hemoglobin, international normalized ratio, lactate dehydrogenase, magnesium, hematocrit, prothrombin time, partial thromboplastin time, mean corpuscular hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin concentration
Surgery characteristics (20)	Aortic cross-clamp time, cardiopulmonary bypass time, time in operation theatre, surgery procedure (from logistic regression text model, see Supplementary Note 1)
Vital signs (8)	Systolic, mean and diastolic arterial pressure, central venous pressure, heart frequency, pulse, body temperature, oxygen saturation
Arterial blood gas values (BGA) (15)	Base excess, bicarbonate, glucose, hemoglobin, oxygen saturation, partial pressure of carbon dioxide and oxygen, total carbon dioxide, pH level, potassium, sodium, calcium, lactate, carboxyhemoglobin, oxyhemoglobin
Fluid output (2)	Bleeding Rate, urine flow rate
Nephrotoxic agents (22)	Allopurinol, Aminoglycosides, Amphotericin B, Antiplatelet agents (clopidogrel, ticlopidine), Benzodiazepines, Cephalosporins, Cyclosporine, Haloperidol, Ketamine, Nonsteroidal anti-inflammatory drugs, Paracetamol, Penicillines, Proton pump inhibitors, Pyrazolone derivatives, Quinolones, Ranitidine, Rifampin, Sulfonamides, Tacrolimus, (Val-)/Ganciclovir, Aciclovir, Vancomycin Red Blood Cell Transfusions