Table 1. Pulmonary pathological findings in the autopsies of 13 patients who were positive for SARS-CoV-2.
Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
Duration of disease (days) | 12 | 16 | 7 | 6 | 12 | 22 | 23 | 32 | 27 | 34 | 33 | 40 | 32 |
Mechanical ventilation (days) | none | 12 | none | none | none | 7 | 8 | 6 | 20 | 15 | 24 | 31 | 22 |
Lung weight (g, both lungs) | 1990 | 2650 | 2200 | 2150 | 2100 | 2350 | 650 | 2100 | 2350 | 2400 | 840 | 2240 | 2100 |
Demonstration of microthrombi | no | yes | yes | yes | no | no | yes | no | yes | no | no | no | yes |
Alveolar edema | diffuse | focal | diffuse | focal | patchy | focal | no | no | no | focal | no | focal | diffuse |
Alveolar hemorrhage | no | no | focal | focal | no | focal | focal | focal | patchy | focal | focal | focal | no |
Hyaline membranes | patchy | focal | patchy | patchy | patchy | patchy | focal | none | focal | focal | patchy | focal | none |
Hyperplasia of type II pneumocytes | none | patchy | focal | marked | focal | focal | patchy | patchy | patchy | patchy | patchy | patchy | focal |
Squamous metaplasia | no | focal | no | patchy | focal | no | focal | focal | focal | focal | focal | focal | focal |
Polynucleated cells | no | yes | no | no | no | yes | yes | no | yes | yes | yes | no | no |
Acute inflammation | none | none | patchy | patchy | none | patchy | none | none | patchy | patchy | no | patchy | patchy |
Lymphohistiocytic inflammation* | M | PB | PB | PB, I | I | PB, I | PB, I | PB, I | I | I | PB, I | PB, I | PB, I |
Interstitial fibrosis | none | mild/focal | none | mild/focal | mild/focal | none | none | mild/focal | marked | marked | marked | mild/ focal | mild/focal |
*classification: M, mild; PB, peribronchial aggregates; I, interstitial aggregates