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. 2020 Oct 23;64(5):819–830. doi: 10.1042/EBC20200012

Figure 2. Structures of RecQ helicases.

Figure 2

(A) Structures of the five human RecQ family members RECQL1 [43], BLM [46], WRN [49], RECQL4 [48] and RECQL5 [47] viewed from the same orientation, with domains color coded as for Figure 1A. (B) Structures of current RecQ DNA complexes RECQL1-DNA [44], BLM-DNA [46], C.s RECQ-DNA [57] and C.s RECQ-G4DNA [58]. (C) Close up view of the interface between the WH β-hairpin and DNA. In RECQL1 [44] and WRN [52], aromatic residues on the β-hairpin make stacking interactions with unpaired DNA bases, whilst the β-hairpins on BLM [46] and C. sakazakii RECQ [57] are shorter and more polar.