Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Current evidence suggests several underlying etiological factors in ALS. Genomic instability, caused by defective DNA damage signalling or DNA repair, toxic DNA repair, impaired clearance of endogenous genotoxic stressors (i.e. ROS), or due to imbalanced chromatin structure states, could be a unifying pathophysiological characteristic of the disease.
