Table 3.
Univariate and Multivariate Analysis of Risk Factors for OS and PFS in LACC Patients Undergoing NACT
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| OS | ||||
| Response to NACT (no vs yes) | 3.250 (1.544–6.838) | 0.002 | 2.453 (1.125–5.348) | 0.024 |
| Age (≥45 y vs <45 y) | 1.193 (0.558–2.551) | 0.649 | - | - |
| Primary tumor size (≥5 cm vs <5 cm) | 1.741 (0.843–3.593) | 0.134 | - | - |
| Primary tumor size (≥6 cm vs <6 cm) | 1.789 (0.767–4.176) | 0.179 | - | - |
| Histology (others vs squamous) | 2.048 (0.910–4.609) | 0.083 | - | - |
| FIGO stage (IIA1-IIA2 vs IB2) | 2.233 (1.022–4.876) | 0.044 | 2.046 (0.933–4.490) | 0.074 |
| Histologic grade (G3 vs G1-G2) | 1.357 (0.623–2.957) | 0.442 | - | - |
| Lymph node metastasis (positive vs negative) | 2.572 (1.253–5.280) | 0.010 | 1.652 (0.711–3.839) | 0.243 |
| LVSI (positive vs negative) | 2.560 (1.229–5.334) | 0.012 | 1.686 (0.710–4.006) | 0.237 |
| Parametrial involvement (positive vs negative) | 1.979 (0.806–4.860) | 0.137 | - | - |
| Surgical margin (positive vs negative) | 1.874 (0.255–13.794) | 0.538 | - | - |
| PFS | ||||
| Response to NACT (no vs yes) | 2.583 (1.452–4.596) | 0.001 | 2.196 (1.183–4.076) | 0.013 |
| Age (≥45 y vs <45 y) | 0.728 (0.408–1.299) | 0.283 | - | - |
| Primary tumor size (≥5 cm vs <5cm) | 1.700 (0.956–3.025) | 0.071 | - | - |
| Primary tumor size (≥6 cm vs <6cm) | 2.019 (1.026–3.973) | 0.042 | 2.013 (0.995–4.071) | 0.052 |
| Histology (others vs squamous) | 1.276 (0.616–2.641) | 0.512 | - | - |
| FIGO stage (IIA1-IIA2 vs IB2) | 1.902 (1.040–3.479) | 0.037 | 1.600 (0.868–2.947) | 0.132 |
| Histologic grade (G3 vs G1-G2) | 0.874 (0.460–1.660) | 0.680 | - | - |
| Lymph node metastasis (positive vs negative) | 2.120 (1.180–3.809) | 0.012 | 1.098 (0.531–2.269) | 0.801 |
| LVSI (positive vs negative) | 2.344 (1.290–4.261) | 0.005 | 1.392 (0.632–3.063) | 0.411 |
| Parametrial involvement (positive vs negative) | 2.703 (1.365–5.353) | 0.004 | 1.688 (0.700–4.068) | 0.243 |
| Surgical margin (positive vs negative) | 2.236 (0.541–9.238) | 0.266 | - | - |
Abbreviations: HR, hazard ratio; CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; LVSI, lymph vascular space invasion; OS, overall survival; PFS, progression-free survival.