Fig. 1.

Schematics of estimating EVs origin from exLR-seq expression profile. (a) An overview of the computational model of EV-origin. (b) The expression pattern and frequency distribution of 810 TSGs among all healthy exLR-seq expression profiles. (c) The circular figure of 95 candidate TSGs represented 16 types of tissue/visceral organs in EV-origin approach. The circularized diagram was developed by five tracks. The first track integrally identifies the official gene ID of all tissue-specific targets with their represented tissues. The second and third tracks represent the expression level of these TSGs in plasma EVs and tissue respectively. The expression frequency and TSS value of each target are illustrated in the last two panels.