Figure 1.

a and a1: The sensitivity of SKOV3 and SKOV3/CDDP cells to cisplatin.

The inhibitory rate of cisplatin on SKOV3-C cells was significantly greater than SKOV3/CDDP-C cells under the same time and concentration (*P < 0.05).

b and b1: Effects of naringin on the proliferation of SKOV3/CDDP cells.

Different concentrations of naringin had different inhibitory effects on SKOV3/CDDP cells with time and dose dependencies. For SKOV3/CDDP cells at 24 hours, there was no significant difference between 10 and 20 μmol/L naringin (P > 0.05); however, there were significant differences between 20 and 40 μmol/L, 20 and 80 μmol/L, and 40 and 80 μmol/L naringin (*P < 0.05). At 48 and 72 hours, there were significant differences between naringin concentrations above 20 μmol/L (** and ^#P < 0.05). Compared with the 24-hour time point, there were significant differences at 48 and 72 hours when the naringin concentration was increased to 40 and 80 μmol/L (** and # compared with *, P < 0.05).

c and c1: For SKOV3/CDDP-N 20 cells, the differences were statistically significant (*P < 0.05) compared with SKOV3-N 20 cells (*P < 0.05). The difference of IC₅₀ values between SKOV3/CDDP-CN 20 cells and the SKOV3-N 20 cells was statistically significant (P < 0.05).

SKOV3/CDDP-C: SKOV3/CDDP cells were treated with different concentrations of cisplatin alone. SKOV3/CDDP-CN 20: SKOV3/CDDP-C cells were treated with 20 μmol/L naringin.