TABLE 4.
Resting state functional connectivity ROI pairs within- and between- DAN, DMN, FPN, and SN network for TSD scans (t-test).
| Network | ROI-to-ROI | t | p-FDR |
| Within-SN | ACC-lAInsula | 11.44 | 0.0000 |
| ACC-lRPFC | 4.03 | 0.0018 | |
| ACC-lSMG | 3.73 | 0.0028 | |
| ACC-rAInsula | 7.87 | 0.0000 | |
| ACC-rRPFC | 3.83 | 0.0025 | |
| ACC-rSMG | 4.12 | 0.0017 | |
| lAInsula-lRPFC | 6.02 | 0.0000 | |
| lAInsula−lSMG | 7.79 | 0.0000 | |
| lAInsula-rAInsula | 11.61 | 0.0000 | |
| lAInsula-rRPFC | 4.70 | 0.0003 | |
| lAInsula-rSMG | 5.18 | 0.0001 | |
| lRPFC-lSMG | 5.48 | 0.0001 | |
| lRPFC-rAInsula | 3.88 | 0.0026 | |
| lRPFC-rRPFC | 8.92 | 0.0000 | |
| lRPFC-rSMG | 3.39 | 0.0072 | |
| lSMG-rAInsula | 4.30 | 0.0010 | |
| lSMG-rRPFC | 3.42 | 0.0046 | |
| lSMG-rSMG | 8.12 | 0.0000 | |
| rAInsula-rRPFC | 7.72 | 0.0000 | |
| rAInsula-rSMG | 8.66 | 0.0000 | |
| rRPFC-rSMG | 8.07 | 0.0000 | |
| Within-FPN | lLPFC-lPPC | 7.51 | 0.0000 |
| lLPFC-rLPFC | 4.90 | 0.0003 | |
| lLPFC-rPPC | 6.21 | 0.0000 | |
| lPPC-rLPFC | 6.50 | 0.0000 | |
| lPPC-rPPC | 11.36 | 0.0000 | |
| rLPFC-rPPC | 6.30 | 0.0000 | |
| Within-DMN | lLP-MPFC | 6.18 | 0.0000 |
| lLP-PCC | 6.52 | 0.0000 | |
| lLP-rLP | 13.70 | 0.0000 | |
| MPFC-PCC | 5.60 | 0.0001 | |
| MPFC-rLP | 6.86 | 0.0000 | |
| PCC-rLP | 5.35 | 0.0002 | |
| Within-DAN | lFEF-lIPS | 4.31 | 0.0028 |
| lFEF-rFEF | 5.42 | 0.0004 | |
| lFEF-rIPS | 3.03 | 0.0230 | |
| lIPS-rFEF | 4.11 | 0.0018 | |
| lIPS-rIPS | 13.56 | 0.0000 | |
| rFEF-rIPS | 3.69 | 0.0062 | |
| SN-FPN | ACC-lLPFC | 4.64 | 0.0006 |
| ACC-lPPC | 2.60 | 0.0302 | |
| ACC-rLPFC | 4.88 | 0.0005 | |
| lAInsula-lLPFC | 3.80 | 0.0021 | |
| rSMG-rLPFC | 4.11 | 0.0012 | |
| lRPFC-lLPFC | 5.04 | 0.0002 | |
| lSMG-lPPC | 6.43 | 0.0000 | |
| lSMG-lLPFC | 3.27 | 0.0060 | |
| lSMG-rPPC | 2.96 | 0.0113 | |
| rAInsula-rLPFC | 3.41 | 0.0053 | |
| ACC-rPPC | 3.52 | 0.0041 | |
| rRPFC-rLPFC | 5.79 | 0.0000 | |
| rRPFC-rPPC | 2.41 | 0.0450 | |
| rSMG-rPPC | 4.07 | 0.0012 | |
| SN-DMN | lAInsula-lLP | −3.94 | 0.0017 |
| lAInsula-PCC | −2.50 | 0.0311 | |
| lAInsula-rLP | −2.64 | 0.0248 | |
| lRPFC−PCC | 3.03 | 0.0142 | |
| lSMG-MPFC | −3.53 | 0.0040 | |
| rAInsula-lLP | −3.32 | 0.0058 | |
| rAInsula-PCC | −2.58 | 0.0283 | |
| rAInsula-rLP | −5.32 | 0.0001 | |
| rRPFC-PCC | 2.71 | 0.0271 | |
| rRPFC-rLP | −2.70 | 0.0271 | |
| SN-DAN | lAInsula-lIPS | 4.73 | 0.0003 |
| lAInsula-rIPS | 3.45 | 0.0043 | |
| lSMG-lIPS | 8.92 | 0.0000 | |
| lSMG-rIPS | 3.95 | 0.0019 | |
| rAInsula-lIPS | 2.29 | 0.0491 | |
| rAInsula-rIPS | 6.61 | 0.0000 | |
| rSMG-rIPS | 7.79 | 0.0000 | |
| rSMG-lIPS | 2.97 | 0.0132 | |
| FPN-DMN | lLPFC-lLP | 3.15 | 0.0086 |
| rPPC- lLP | 10.79 | 0.0000 | |
| lPPC-lLP | 4.63 | 0.0004 | |
| lPPC-PCC | 2.47 | 0.0445 | |
| rLPFC-PCC | 2.83 | 0.0181 | |
| lLPFC- rLP | 5.50 | 0.0001 | |
| lPPC-rLP | 9.55 | 0.0000 | |
| rPPC-rLP | 3.77 | 0.0034 | |
| FPN-DAN | lPPC-lIPS | 3.94 | 0.0019 |
| lLPFC-lIPS | 3.69 | 0.0035 | |
| rLPFC-lFEF | −3.80 | 0.0027 | |
| rLPFC-rFEF | −3.03 | 0.0126 | |
| rPPC-lFEF | −3.63 | 0.0035 | |
| rPPC-rFEF | −3.68 | 0.0035 |
FDR, false discovery rate; ROI, region of interest; TSD, total sleep deprivation. p < 0.05 FDR set wise corrected for all comparisons across the entire network. DAN, dorsal attention network; DMN, default mode network; FPN, fronto-parietal network; SN, salience network.