FIGURE 1.

Effect of administration of different doses (0.1, 10 and 50 μg) of PepN during sensitization on airway inflammation of OVA‐induced allergic asthma. (a) Experimental protocol. (b) Total inflammatory cells and eosinophils in bronchoalveolar lavage fluid. (c) Th2 cytokine (IL‐5 and IL‐13) levels in bronchoalveolar lavage fluid (BALF). (d) Photomicrographs of H&E‐ and PAS‐stained lung tissue sections of mice (400× magnification) and semi‐quantified PAS score. (e) Muc5ac mRNA expression levels in mouse lung tissues. (f) IgE levels in BALF and serum. (g) IFN‐γ and IL‐17A levels in BALF. (h) Th2 cytokines (IL‐4, IL‐5 and IL‐13) levels in spleen cells re‐stimulated with 200 μg·ml⁻¹ OVA for 72 h. The results were representative of three independent experiments. Data were presented as means ± SEM (n = 6–8). ^* P < 0.05, n.s., not significant