Table 2.
Baseline characteristics, vital signs at the time of presentation to the hospital, and underlying comorbidities in comprehensive analysis colchicine and control groups (only including patients having at least two different timepoint measurements for at least two inflammatory markers (either D-dimer, CRP, LDH, or ferritin)). Age and pulse rate were normally distributed; the independent t-test was used to compare the two groups. BMI, temperature, oximetry (SpO2), and respiratory rate were nonnormally distributed; the Mann–Whitney U test was used to compare the two groups. The χ2 test was used to compare the gender, patients on room air, oxygen by a nasal cannula, a nonrebreather mask, the prevalence of HTN, DM, and renal failure in the two groups. Fisher's exact test was used to compare the number of patients intubated at the time of presentation, the prevalence of asthma, COPD, hypothyroidism, and CAD in the two groups.
| Colchicine group (N = 34) | Control group (N = 78) | P value | |
|---|---|---|---|
| Demographics | |||
| Age (mean ± SD) | 67.7 ± 12.3 | 66.4 ± 13.3 | 0.626 |
| Gender, male (percentage) | 21 (61.8) | 40 (51.3) | 0.306 |
| BMI (median) | 27.4 | 27.5 | 0.613 |
| Vital signs at the time of presentation to the hospital | |||
| Pulse rate (mean ± SD) | 99.7 ± 19.1 | 99.5 ± 20.9 | 0.973 |
| Respiratory rate (median) | 20 | 22 | 0.631 |
| Temperature (median) | 99.95 | 98.8 | 0.020 |
| Initial SpO2 (median) | 95.5 | 94 | 0.247 |
| On room air when initial SpO2 obtained (percentage) | 9 (26.5) | 32 (41) | 0.141 |
| On oxygen by a nasal cannula when initial SpO2 obtained (percentage) | 17 (50) | 23 (29.5) | 0.037 |
| On a nonrebreather mask when initial SpO2 obtained (percentage) | 7 (20.6) | 19 (24.4) | 0.664 |
| Intubated when initial SpO2 obtained (percentage) | 1 (2.9) | 4 (5.1) | 1.00 |
| Comorbid illnesses | |||
| HTN | 18 (52.9) | 56 (71.8) | 0.053 |
| DM | 11 (32.4) | 40 (51.3) | 0.064 |
| Asthma | 1 (2.7) | 8 (10) | 0.272 |
| COPD | 5 (14.7) | 6 (7.7) | 0.304 |
| Hypothyroidism | 3 (8.8) | 3 (3.8) | 0.365 |
| CAD | 2 (5.9) | 6 (7.7) | 1.00 |
| Renal failure | 12 (35.2) | 47 (60.3) | 0.015 |
HTN, hypertension; DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease; CAD, coronary artery disease; CKD, chronic kidney disease.