Table 1.
Parameters of the T cell Response Model
Parameter | Value | Description | Dimension |
---|---|---|---|
a | 0.4 | Proliferation rate of activated Tconvs | molecule−1time−1 |
b | 0.1 | Natural death rate of activated Tconvs and Tregs | time−1 |
c | Fratricide death rate of activated Tconvs | cell−1time−1 | |
d | 0.01 | IL-2 secretion rate by activated Tconvs | molecule cell−1time−1 |
e | 0.01 | IL-2 consumption rate by activated Tconvs and Tregs | cell−1time−1 |
f | 1 | IL-2 decay rate | time−1 |
g | 0.1 | Natural death rate of naïve Tconvs and resting Tregs | time−1 |
β | 0.05 | Ag stimulation of naïve Tconvs and resting Tregs | time−1 |
γ | 0.1 | Treg-mediated suppression rate | cell−1time−1 |
ε | 0.6 | Ratio of proliferation rates of Tregs to Tconvs | – |
λ | 0.006 | Ratio of renewal rates of resting Tregs to naïve Tconvs | – |
4 | Renewal rate of naïve Tconvs | cell time−1 | |
Renewal rate of resting Tregs | cell time−1 |