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Chronological life span in budding yeast with mutated rDNA. Two old-mouse-specific mutations in the 28S rRNA gene were introduced into the budding yeast 25S rRNA gene, and the chronological life spans of the yeast were measured for the strains with A2131G and A3295G mutations in the 25S rRNA gene, as indicated. The values are the average of nine experiments. WT, wild type.
