TABLE 2.
Sequence variation at BamHI recognition sequences in young and old micea
| Position in 28S | Mutation rateb in: |
|||||||
|---|---|---|---|---|---|---|---|---|
| BALB/cA mice |
C57BL/6 mice |
|||||||
| Young (avg, 0.25) |
Old (avg, 0.685) |
Young (avg, 0.44) |
Old (avg, 0.38) |
|||||
| Male 3 | Female 1 | Male 3 | Male 4 | Male 1 | Female 1 | Male 1 | Female 1 | |
| G5050 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| G5051 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| A5052 | 0.23 | 0.27 | 0.35 | 0.32 | 0.22 | 0.25 | 0.21 | 0.21 |
| T5053 | 0.00 | 0.00 | 0.19 | 0.16 | 0.09 | 0.11 | 0.09 | 0.08 |
| C5054 | 0.00 | 0.00 | 0.19 | 0.16 | 0.08 | 0.11 | 0.09 | 0.08 |
| C5055 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
a
The sequences of the original and mutated BamHI sites are 5′-GGATCC-3′ and 5′-GGGGTC-3′, respectively (mutated sequence underlined). avg, average sum of the mutation rates.
b
The mutation rates of mutated sequences are in boldface.