Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 21;12(10):3066. doi: 10.3390/cancers12103066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Domain organization of RasGAPs (Ras GTPase-Activating Proteins). In addition to the GAP domain, different RasGAP proteins are characterized by a specific array of functional domains, orchestrating their subcellular localization and regulation (SH2 = Src homology 2 domain; SH3 = Src homology 3 domain; PH = plekstrin homology domain; C2 = calcium-dependent phospholipid-binding motif; CSR = Cys/Ser-rich region; SEC14 = CRAL-TRIO lipid-binding domain; CTD = C-terminal domain; Z = Btk-type zinc finger motif; PER = period-like domain; PR = proline-rich region). Representative proteins are drawn based on UniProtKB entries (2020_05 release, https://www.uniprot.org/). Note that NF1 is not drawn to scale.