Figure 1.

Chronology of epigenetics. From top to bottom: Dates (blue): from 1865 to today; Nobel Prizes (salmon) associated with major genetic or epigenetic discoveries; major dates (gray): important discoveries concerning DNA and chromatin; epigenetic proteins (white): year of identification or main writers, readers and erasers of epigenetics (a color code has been associated to proteins involved in a same pathway, e.g., blue for HAT (histone acetyl transferase)); epidrugs in the clinic (green): use of main epidrugs in clinical trials.