Table 2.
Minimum inhibitory concentrations in μM (μg/mL) of synthetic replicates of ocellatins isolated from skin secretions of L. insularum and L. nesiotus against reference and antibiotic-resistant strains of Gram-positive and Gram-negative bacteria.
| Bacteria | Ocellatin-1I | Ocellatin-2I | Ocellatin-1N | Ocellatin-3N |
|---|---|---|---|---|
| Gram-positive | ||||
| S. aureus (ATCC 12600) | 250 (575) | >250 (>620) | 250 (725) | 31.25 (67) |
| S. aureus (ATCC BAA-2312) | 250 (575) | >250 (>620) | 250 (725) | 31.25 (67) |
| E. faecium (ATCC 19434) | n.d. | 250 (620) | 250 (725) | 62.5 (134) |
| E. faecalis (ATCC 51299) | >250 (>575) | >250 (>620) | >250 (>725) | 250 (535) |
| Gram-negative | ||||
| E. coli (ATCC 35218) | 62.5 (144) | 62.5 (155) | 62.5 (181) | 31.25 (67) |
| K. pneumoniae (ATCC 49472) | 125 (288) | 125 (310) | 125 (362) | 62.5 (134) |
| K. pneumoniae (ATCC BAA-2814) * | >125 (>288) | 125 (310) | 125 (362) | 62.5 (134) |
| P. aeruginosa (ATCC 27853) | n.d. | >125 (>310) | >125 (>362) | 62.5 (134) |
| S. typhimurium (ATCC 14028) | 250 (575) | 125 (310) | 250 (725) | 62.5 (134) |
n.d., not determined. * denotes an antibiotic-resistant strain.