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. 2020 Oct 19;12(10):989. doi: 10.3390/pharmaceutics12100989

Figure 1.

Figure 1

Immunization with CpG-ODN-adjuvanted Toxoplasma gondii virus-like particles (VLPs) enhances T. gondii-specific IgG (A) and IgA (B) antibody production in the sera upon one, two, and three immunizations. Groups of mice (n = 6 per group) were intranasally immunized one, two, or three times with T. gondii VLPs alone or CpG-ODN-adjuvanted T. gondii VLP vaccine. Booster vaccinations were provided at 4-week intervals. Mouse sera were collected at 4 weeks after each immunization to detect the levels of IgG (A) and IgA (B) antibodies by ELISA. Results are presented as mean ± SD and statistical significances were denoted using asterisks (* p < 0.05, ** p < 0.01, and *** p < 0.001).