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. 2020 Oct 19;12(10):989. doi: 10.3390/pharmaceutics12100989

Figure 4.

Figure 4

Immunization with CpG-ODN-adjuvanted T. gondii VLPs enhances CD4+ (A,C) and CD8+ (B,D) T-cell frequencies. BALB/c mice (n = 6 per group) immunized one, two, or three times were challenge-infected with T. gondii ME49, 4 weeks after the last immunization. Spleen and MLN tissues were harvested at 35 dpi and then cell phenotypes were determined by flow cytometry with or without T. gondii antigen stimulation. Results are presented as mean ± SD and statistical significances were denoted using asterisks (*** p < 0.001).