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. 2020 Oct 20;12(10):997. doi: 10.3390/pharmaceutics12100997

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Local sensitivity analysis of the PBPK model for 1,1-difluoroethane (DFE). Normalized sensitivity coefficients (ratios between percentage change in DFE and percentage change in model parameter) were calculated for DFE in mixed venous blood at 24 h with a standard man (BMI 24.2) and scenario Y. Parameters with sensitivity coefficients between −0.1 and 0.1 are not shown. Vf—volume of fat compartment; PCfb—fat:blood partition coefficient; BW—body weight; BMI—body mass index; PCba—blood:air partition coefficient; Vm—volume of muscle compartment; PCmb—muscle:blood partition coefficient; Qvrg—blood flow of rapidly perfused organ; Qliv—liver blood flow; Qalv—alveolar ventilation; W—physical workload; Qfat—fat blood flow.