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. 2020 Oct 20;12(10):997. doi: 10.3390/pharmaceutics12100997

Table 1.

Model parameter used in the physiologically based pharmacokinetic (PBPK) simulations. The presented volumes and flows correspond to those of a resting “standard man” (body weight 70 kg, height 170 cm, body mass index (BMI) 24.2) at near rest (physical workload 10 W).

Compartment Volume (L) 1 Flow (L/min) 1 Partition Coefficient 2
Alveolar ventilation - 8.90 Blood:air 1.08
Lungs and arterial blood 1.44 6.32 Lung:blood 1.24
Rapidly perfused tissues (VRG) 2.09 3.20 VRG:blood 1.24
Fat tissues 15.43 0.34 Fat:blood 3.94
Muscles 17.45 1.15 Muscle:blood 1.34
Liver 3 1.48 1.64 Liver:blood 0.88

1 Volumes and flows were scaled in the Monte Carlo simulations according to Nihlén and Johanson [42]. 2 See Ernstgård et al. [41] for sources. 3 Metabolism assumed to be zero. Reproduced with permission from [41]; Published by Elsevier, 2014.