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. 2020 Oct 13;21(20):7537. doi: 10.3390/ijms21207537

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sphingosine-1-phosphate receptors (S1PRs) expression and main transduction pathways activated in oligodendrocytes progenitor cells (OPCs) and oligodendrocytes. (A) Schematic representation of G-protein coupled receptors and main pathways involved after receptor activation. Sphingosine-1-phosphate receptor 1,2,3,5 (S1PR1,2,3,5); mitogen-activated protein kinase (MEK); extracellular signal-regulated kinases (ERK); phosphatidylinositol 3-kinase (PI3K); phosphatidylinositol (3,4,5)-trisphosphate (PIP3); 3-phosphoinositide dependent protein kinase-1 (PDK1); protein kinase B (Akt); phospholipase C (PLC); protein kinase C (PKC); Rho-associated protein kinase 1 (ROCK); collapsin response mediator protein (CRMP). (B) S1PRs expression levels in human OPCs and oligodendrocytes [71,72,73,74,75].