MS	Multiple sclerosis
CNS	Central nervous system
S1PR	Sphingosine-1-phosphate receptor
OPC	Oligodendrocyte progenitor cell
Shh	Sonic hedgehog
Olig	Oligodendrocyte transcription factor
Nkx6.1	Homeobox protein Nkx-6.1
Sox	Sex determining region Y-box
PDGFα	Platelet-derived growth factor-alpha
PDGFRα	PDGFα receptor
PLP	Protein proteolipid protein
MBP	Myelin basic protein
MAG	Myelin-associated glycoprotein
GalC	Galactocerebroside
MOG	Myelin-oligodendrocyte glycoprotein
BBB	Blood-brain barrier
ROS	Reactive oxygen species
DMTs	Disease modifying therapies
SEMA4D	Semaphorin-4D
PMS	Progressive multiple sclerosis
SPMS	Secondary progressive multiple sclerosis
S1P	Sphingosine-1-phosphate
SphK	Sphingosine kinase
MAP	Mitogen-activated protein
PI3K	Phosphoinositide 3-kinase
PLC	Phospholipase C
NK	Natural killer
ERK	Extracellular signal-regulated kinase
Akt	Protein kinase B
PIP3	Phosphatidylinositol (3,4,5)-trisphosphate
PDK1	3-phosphoinositide dependent protein kinase-1
CREB	cAMP response element-binding protein
p38MAPK	p38 mitogen-activated protein kinase
MEK	Mitogen-activated protein kinase
ROCK	Rho-associated protein kinase 1
CRMP	Collapsin response mediator protein
FDA	Food and drug administration
RRMS	Relapsing-remitting multiple sclerosis
EAE	Experimental autoimmune encephalomyelitis
CIS	Clinically isolated syndrome
BDNF	Brain-derived neurotrophic factor
LIF	Leukemia inhibitory factor
HBEGF	Heparin-binding EGF-like growth factor
LPC	Lysolecithin
Nrf2	Nuclear factor erythroid 2–related factor 2
HO-1	Heme oxygenase
NQO1	NAD(P)H: quinone acceptor oxidoreductases-1
p.o.	post-onset
PPMS	Primary progressive form of MS
d.p.i	Day post immunization
GLAST	Glutamate-aspartate transporter
GLT-1	Glutamate transporter-1
IL	Interleukin
ARR	Annualized relapse rate
LPS	Lipopolysaccharides
TNFα	Tumor necrosis factor α