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. 2020 Oct 9;21(20):7451. doi: 10.3390/ijms21207451

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A schematic of arachidonic acid’s hydroxyeicosatetraenoic (HETE), and epoxyeicosatrienoic acid (EET) derivatives and their relationships. HETEs are created by both the lipoxygenase (5-HETE, 12-HETE, 15-HETE) and cytochrome P450 (16-HETE, 18-HETE, 19-HETE, 20-HETE) pathways with dihydroxyeicosatraenoic acid (DiHETE) derived from EET by soluble expoxide hydrolase. 20-carboxy-arachidonic acid (20-COOH-AA) is a metabolite of 20-HETE. Eicosanoids that were significantly different in the vitreous of control and PDR eyes in the current study are shown in bold font COX = cyclooxygenase. HETEs and their derivatives have a role in pro-angiogenic processes [17,18,19,20,21,22,23,24,25,26,27,28].