Table 2.
Mean levels (pg/mL) +/− standard error of measurement (SEM) of lipoxygenase and cytochrome P450-derived eicosanoids in bevacizumab-treated human vitreous in vitreous hemorrhage (VH, n = 11) vs. tractional retinal detachment (TRD, n = 8) eyes.
| Metabolite | VH ± SEM (11) | TRD ± SEM (8) | p-Value |
|---|---|---|---|
| 5-HETE | 55.772 ± 36.114 | 19.088 ± 5.708 | 0.3383 |
| 12-HETE | 29.164 ± 15.587 | 10.575 ± 3.046 | 0.2671 |
| 15-HETE | 73.273 +/− 53.75 | 13.575 ± 7.183 | 0.2959 |
| 20-HETE | 7.927 ± 2.169 | 10.213 ± 4.280 | 0.6436 |
| 20-COOH-AA | 119.518 ± 34.719 | 87.338 ± 41.407 | 0.5603 |
| Total ꞷ-hydroxylase level | 127.446 ± 36.211 | 97.550 ± 44.996 | 0.6124 |
| 12-HETrE | 69.355 ± 24.072 | 21.713 ± 10.290 | 0.0913 |
| 11,12-EET | 25.645 ± 10.543 | 12.563 ± 6.829 | 0.313 |
| 14,15-EET | 37.381 ± 13.720 | 18.838 ± 9.437 | 0.2815 |
| 11,12-DiHETE | 38.691 ± 8.852 | 18.829 ± 5.510 | 0.0658 |
| 14,15-DiHETE | 50.582 ± 10.828 | 31.414 ± 5.510 | 0.1366 |
| Total epoxygenase level | 212.363 ± 67.437 | 103.200 ± 30.979 | 0.1638 |