FIGURE 1.
Arctigenin produces antidepressant‐like effects in the TST and FST. (a) The chemical structure of arctigenin. (b) Schematic timeline of experimental procedures. arctigenin (AG; 25, 50, or 100 mg·kg−1) or sertraline (SERT; 10 mg·kg−1) decreased the immobility time in the TST (c) and FST (d) in a dose‐dependent manner. (e) Arctigenin (25, 50, or 100 mg·kg−1) or sertraline (10 mg·kg−1) had no effect on the spontaneous locomotor activity in the OFT. The data are expressed as means ± SEM (n = 10). # P < 0.05, significantly different from control group; one‐way ANOVA followed by post hoc Tukey's test