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. 2020 Oct 20;12(10):3052. doi: 10.3390/cancers12103052

Figure 1.

Figure 1

MYC overexpression is associated with reduced T cell-mediated anti-tumor immune responses and impaired innate anti-tumor immune responses by macrophages and NK cells, but not NK cells with the NKp30 receptor. Top left: simplified summary of adaptive immune responses towards malignant cells with normal MYC expression. Top right: MYC overexpression decreases expression of MHC class I and class II molecules, adhesion and costimulatory molecules. MYC overexpression is associated with reduced cytotoxic T cell responses. Different outcomes on the correlation between MYC overexpression and expression of immune checkpoint programmed death-ligand 1 (PD-L1) have been described. Bottom left: simplified summary of innate immune responses towards malignant cells with normal MYC expression. Bottom right: MYC overexpression reduces NK cell amounts, but not cytotoxicity induced via NKp30 NK cells. MYC overexpression induces expression of immune checkpoint CD47, preventing macrophage (Mph)-induced phagocytosis.