Figure 3.

Immunotherapeutic treatment strategies and clinically available MYC modulators in lymphoid malignancies. Antibody-mediated therapies include monoclonal antibodies, antibody-drug conjugates, bispecific antibodies and immune checkpoint inhibitors. Cellular therapies include CAR-T cell therapy and allogeneic stem cell transplantation. Clinically available MYC modulators are lenalidomide (which reduces MYC protein by stimulating Cereblon, subsequently degrading IKZF1 and IKZF3, followed by downregulation of IRF4), idelalisib (PI3K inhibitor) and fimepinostat (combined PI3K and HDAC inhibitor). Preclinical MYC modulators are bromodomain (BRD) inhibitors (e.g., JQ1) and MYC/MAX dimerization inhibitors.