Table 3.

Studies evaluating safety of sublingual immunotherapy in young children.

Author, Year	Allergen Extract	Age (Year)	Population (Total Patients, Active/Control Groups If Applicable)	AIT Duration (Months)	Main Results
Agostinis et al., 2004 [81]	HDM, grass	1–3	36	12–36	SLIT can be safely administered to very young children.
Di Rienzo et al., 2005 [78]	Various	3–5	126	24	SLIT is safe in children under the age of 5 years.
Fiocchi et al., 2005 [82]	Various	3–6	65	12	High-dose immunotherapy in children younger than 5 years is as safe as in older children.